Posted Date: Nov 5 2019
GSK is seeking a highly motivated and experienced mechanistic modeling scientist to join our recently formed Drug Metabolism and Pharmacokinetics modeling team. As a scientific leader with supervisory responsibility, the successful applicant will develop and drive the preclinical PK/PD strategy for projects with the aim to deliver a robust prediction of the human efficacious dose.
Key Responsibilities include:
•Interface with the therapeutic areas, acting as point of contact between DMPK, and other discovery (chemistry, biology, safety), and development colleagues to design and analyse the appropriate preclinical studies.
• Responsible for project deliverables, including prediction of human PK, preclinical and translational PK/PD work in projects from target validation to candidate selection and human dose in conjunction with DMPK modeling director, clinical pharmacologists, translational scientists and the DMPK Project Representative.
• Establish and implement PK/PD strategies to facilitate continuous improvement of human dose prediction.
•Interface with biology and clinical teams to implement biomarker strategy
•Evaluate and interpret PK/PD data to prepare for internal governance bodies.
• Work with DMPK modeling scientists, DMPK Project Representatives, functional lines and other enterprise business partners to assure timely project issue resolution
• Drive the rapid development of applied modeling innovation in partnership with external and internal groups
• Present work at cross-functional teams, departmental meetings
• Provide expert DMPK modeling consultancy, training and support to scientists within the DMPK organization and across the larger R&D
• Active engagement with external modeling community and maintain awareness of new /emerging techniques relevant to the field.
•Manage student and post doc programmes
•Act as mentor to junior staff within the DMPK modeling team
The ideal candidate will be/have:
- A successful track record of applying translational PK/PD modeling within the drug discovery and development environment.
- Experience in providing PK/PD input into early preclinical in vivo studies
- Understanding of the principles of ADME and pharmacokinetics, (non-compartmental, compartmental, PBPK) and the use of pre-clinical data for human efficacious dose prediction.
- Experience in PK data interpretation of a range of clinical studies
- Experience in DMPK project co-ordination.
- Experience of interacting with regulatory agencies in the area of modeling and simulation.
- The ability to work independently, excellent interpersonal, organizational, oral/written communication and teamwork skills
- Ability to multi task and prioritize to deliver results within tight timelines when required.
- Active contributions to external consortia; presenting at conferences and contribution to scientific publications.
- Advanced degree (PhD) in relevant scientific discipline (e.g. Pharmacology, pharmaceutical sciences), with several years' experience in DMPK and PK/PD within a drug discovery environment.
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