Modeling Scientist

08 Nov 2019
06 Dec 2019
Contract Type
Full Time
Site Name: Stevenage, USA - Pennsylvania - Upper Providence, Ware RD
Posted Date: Nov 5 2019

GSK is seeking a highly motivated and experienced mechanistic modeling scientist to join our recently formed Drug Metabolism and Pharmacokinetics modeling team. As a scientific leader with supervisory responsibility, the successful applicant will develop and drive the preclinical PK/PD strategy for projects with the aim to deliver a robust prediction of the human efficacious dose.

Key Responsibilities include:
•Interface with the therapeutic areas, acting as point of contact between DMPK, and other discovery (chemistry, biology, safety), and development colleagues to design and analyse the appropriate preclinical studies.
• Responsible for project deliverables, including prediction of human PK, preclinical and translational PK/PD work in projects from target validation to candidate selection and human dose in conjunction with DMPK modeling director, clinical pharmacologists, translational scientists and the DMPK Project Representative.
• Establish and implement PK/PD strategies to facilitate continuous improvement of human dose prediction.
•Interface with biology and clinical teams to implement biomarker strategy
•Evaluate and interpret PK/PD data to prepare for internal governance bodies.
• Work with DMPK modeling scientists, DMPK Project Representatives, functional lines and other enterprise business partners to assure timely project issue resolution
• Drive the rapid development of applied modeling innovation in partnership with external and internal groups
• Present work at cross-functional teams, departmental meetings
• Provide expert DMPK modeling consultancy, training and support to scientists within the DMPK organization and across the larger R&D
• Active engagement with external modeling community and maintain awareness of new /emerging techniques relevant to the field.
•Manage student and post doc programmes
•Act as mentor to junior staff within the DMPK modeling team


Basic Qualifications
The ideal candidate will be/have:

  • A successful track record of applying translational PK/PD modeling within the drug discovery and development environment.
  • Experience in providing PK/PD input into early preclinical in vivo studies
  • Understanding of the principles of ADME and pharmacokinetics, (non-compartmental, compartmental, PBPK) and the use of pre-clinical data for human efficacious dose prediction.
  • Experience in PK data interpretation of a range of clinical studies
  • Experience in DMPK project co-ordination.
  • Experience of interacting with regulatory agencies in the area of modeling and simulation.
  • The ability to work independently, excellent interpersonal, organizational, oral/written communication and teamwork skills
  • Ability to multi task and prioritize to deliver results within tight timelines when required.
  • Active contributions to external consortia; presenting at conferences and contribution to scientific publications.

Preferred Qualifications

  • Advanced degree (PhD) in relevant scientific discipline (e.g. Pharmacology, pharmaceutical sciences), with several years' experience in DMPK and PK/PD within a drug discovery environment.

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

We're open to all talent - whatever your gender, disability, marital status, religion or belief, age, race, sexual orientation, ethnic or national origin.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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