Molecular Receptor Pharmacologist

Job title:                                  Molecular Receptor Pharmacologist

Location:                                Oxford

Hours:                                     Full-time

Wage:                                     £45,000 pa

Work Pattern:                       Monday – Friday

Employer:                              Exscientia Limited

Duration:                               Permanent

Date advert posted:             3 May 2019

Closing date:                          31 May 2019

Job description

Exscientia is seeking a Molecular Receptor Pharmacologist to join its drug discovery team in Oxford.

Key responsibilities

The key responsibilities involve the following:

• discovering new leads and delivering candidate molecules for novel GPCR projects;
• leading the prosecution of GPCR cell based assays in 96 and/or 384 well format, ensuring highest levels of quality control;
• collaborating with computational chemists to create novel combined experimental & computational processes of GPCR ligand discovery;
• developing novel GPCR screening technologies to detect G-protein/arrestin bias across majority of G-proteins;
• designing and development robust, biosensor screens for GPCR/G-protein complexes;
• executing high-throughput GPCR-G protein bias screens;
• providing expert opinion and troubleshooting on GPCR assay design robustness to internal and external collaborators;
• taking responsibility for quality assurance in the screening process;
• carrying out data analysis and statistical modelling to enable hit selection;
• keeping appropriate experimental records, helping oversee data integrity and confidentiality;
• assisting in the production of high quality reports supporting milestones and deliverables; and
• working closely with the bioinformatics team to select new biological targets.

Essential Qualifications

The successful candidate must possess the following qualification

• PhD in GPCR pharmacology and screening.

Essential Skills & Experience

The successful candidate must have the following skills and experience

• demonstrable experience of performing ligand discovery for GPCR/G-protein bias ligands receptors through high throughput screening preferable in cell-based systems;
• competency in cell culture and an understanding or direct experience of GPCR/G-protein profiling and assay techniques and other GPCR signalling screening methods;
• minimum of three years of relevant molecular biology and screening experience of GPCR molecular pharmacology, demonstrable experience of training in molecular pharmacology in a specialist GPCR laboratory and of working in the pharma/biotech industry or in an academic drug discovery setting;
• demonstrable experience in data analysis and QC of receptor pharmacology screens;
• demonstrable experience in the evaluation interpretation and reporting of data in accordance with high quality scientific practice;
• demonstrable experience of managing multi-site collaborative screening initiatives;
• demonstrable evidence of developing novel GPCR screening technologies experience by authoring high impact publications or patents;
• a demonstrable ability to plan and work in an organise manner and to standard operating procedures;
• proactive, productive and ability to work effectively in teams;
• flexible and able to multi-task with a commitment to quality and scientific rigour;
• excellent project management skills and problem solving and trouble-shooting capabilities;
• familiarity with software for data capture, analysis and presentation;
• highly motivated with a track record of success; and
• working proficiency and communication skills in verbal and written English.

To apply: please upload your CV and a cover letter directly through the portal.

Date posted: 3 May 2019

Closing date: 31 May 2019