Research Associate (Bioinformatics)
- Full Time
Research Associate (Bioinformatics)
Cancer Research UK Cambridge Institute
Salary: £32,236 - £39,609 per annum
As part of the pioneering Integrated Medicine Program (ICM) currently running in the CRUK Cambridge Centre, we aim to recruit a Research Associate to be part of an ambitious project that will integrate in real time multiple data sources from different cancer types with the goal to achieve better clinical treatment decisions.
Specifically, the successful candidate will work with data sets from which genome sequencing (WGS), whole transcriptome sequencing (RNA-SEQ) and image analysis from breast cancer tumours. Different data types (germline variations, somatic mutations, copy number aberrations, structural variations and gene expression data) will be combined in order to detect subsets of events that are coordinated and have a biological function in the tumour. These data-driven pathways will be tested for relevance as biomarkers for prognosis (1-2) and monitored through circulating-tumour DNA (ctDNA) to track response to treatment (3). Information from patient-derived tumour xenografts (PDTXs) avatars will be integrated to offer therapeutic options in the case of metastatic disease (4).
This project will require the development of novel statistical methods; therefore, we are looking for a candidate with a PhD in Statistics, Computational Biology or a related discipline. The work will be carried out within a multidisciplinary laboratory that includes genomic, biological, computational and clinical scientists. Teamwork and ability to communicate ideas and results is required. Advanced knowledge of R is also needed.
The position will be integrated in the Caldas Laboratory at the CRUK Cambridge Institute, although it will be shared with the Statistical Laboratory, where Professor Richard Samworth (Director of the Statistical Laboratory), will act as the second supervisor.
As indicated above, this post-doctoral position will be part of the Integrated Cancer Medicine (ICM) programme. The overarching objective of ICM is to deliver a revolutionary new treatment paradigm for cancer patients. This concept envisages the integration of clinical, laboratory, mathematical and computational science and technology to the point where all patient data is used maximally to guide optimal treatment decisions. The ICM leverages our expertise in cancer genomics, 'liquid biopsies' (detecting tumour DNA in the blood), molecular imaging and 3D tumour mapping to generate Data Streams that simultaneously report the functional biology of tumours among cancer patients receiving active treatment. These data will then be integrated using innovative Cambridge-invented mathematics and statistical algorithms with the goal of charting precision medicine approaches for all patients.
(1)Curtis et al (Nature, 2012)
(2)Rueda et al (Nature, 2019)
(3)Dawson et al (NEJM, 2013)
(4)Bruna, Rueda et al (Cell, 2016)
Fixed-term: The funds for this post are available until 30 June 2021 in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
Click apply below for further information about the position and how to apply!
The closing date is 22 May 2019, with the interview date TBC.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference SW18899 on your application and in any correspondence about this vacancy.
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