Investigator Dawnstream Process Development
Your Responsibilities:
A highly motivated, independent individual with a track record of developing and implementing novel downstream bioprocessing strategies is sought to work within this team. Your duties will include and are not limited to:
•Work collaboratively with Cell & Gene Therapy Platform CMC vector, upstream, analytical and cell process development scientists to establish robust downstream processes, for the purification of viral vectors (lenti and AAV)
•Define and execute experimental strategies to establish a lentivirus downstream processing platforms including in-process testing/controls delivering high lentivirus recoveries whilst maintaining product quality
•Contribute to the definition and delivery of downstream process development programmes outsourced to external Contract Manufacturing Organisations
•Define, develop and validate innovative technologies and approaches to make step changes in lentivirus recovery/purification efficiency
•Support development of a portfolio of ex-vivo gene therapies from early to late stage by providing downstream expert input to project teams, directing development work, reviewing data, supporting regulatory interactions
•Engage with external cell-gene therapy process/manufacturing experts
•Maintain awareness of external technology and patent landscape as well as competitor process technology activity
You will have:
•Experience in downstream process development - primary separations, ultrafiltration/diafiltration, chromatography resin screening, purification development and optimisation
•A track record in the development/scale-up of biologics. Experience with lentivirus or AAV purification would be an advantage.
•Experience of in-process analytical methods and determining critical process parameters (CPP) ideally for viral vectors.
•Experience of process transfer and cGMP manufacturing would be an advantage.
•Excellent communication and project management skills to facilitate interactions with internal groups and with external collaborators and partners.
•Supervisory/management experience of other scientists, students or process operators.
The successful candidate will report to the Scientific Leader of Downstream Process Development within Cell & Gene Therapy Platform CMC.
Closing date for applications: Monday 3rd September 2018
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.
If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact . This will help us to understand any modifications we may need to make to support you throughout our selection process.
When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
Thank you for your interest in this opportunity.
*LI-GSK
Why You?Basic qualifications:
•PhD or equivalent experience in Biological Sciences.
•Experience of downstream process development for viral vectors, biopharmaceuticals or vaccines.
Preferred qualifications:
•Experienced in optimisation and scale up of downstream processes for the production of clinical grade lentivirus or adeno-associated virus (AAV).
•Experience in cell culture harvest strategies, chromatography resin screening and optimisation, ultrafiltration/diafiltration processes to isolate high-quality viral particles (lentiviral or AAV).
•Ability to identify and implement novel downstream manufacturing platforms.
•Experience of sterile filtration and methods for aseptic filling.
Why GSK?:
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery for strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
Contact information:
You may apply for this position online by selecting the Apply now button.
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