Cell Process Development - Principal Scientist 52

Didcot, Oxfordshire, England
10 Aug 2017
07 Sep 2017
Vacancy Filler
Contract Type
Full Time

Principal Scientist

The purpose of this role is to primarily conduct scientific experiments as necessary within dedicated scientific teams. It is likely that the individual will be progressing from a Scientist role from within the company, or will have significant scientific role experience from elsewhere. They will be relatively independent in both the conduct and analysis of their experiments, but will still require guidance from their line manager. This role may or may not involve project management or line management of others. Functional focus: The Cell Process Development team is concerned with the improvement and automation of their T cell manufacturing process, as well as process adaptation and innovation for new products coming from the organisation's pipeline and research groups (incl. Autoimmune and Stem Cell). Cell products from individual stages within the manufacturing process are characterised in phenotypical and functional assays. Process changes are then tech transferred to their global manufacturing teams.

Key responsibilities

Conducting experiments in cell culture and analytical labs (50%)
Experiment planning, data analyses and recording results (15%)
Meetings and discussions (10%)
Routine lab maintenance (5%)
Project management or line management of others (20%, This percentage may rise or fall depending on

Qualifications and Experience

  • Undergraduate degree in Life sciences or related discipline
  • Relevant post-graduate experience, typically with at least 10 years' or equivalent, preferably including an MSc or PhD in a relevant scientific area.
  • Ability to work independently
  • Aseptic cell culture experience, ideally large-scale and/or with primary human T cells
  • In-depth understanding of cell biology and immunology
  • Practical experience in relevant cell biology assays
  • Project and team leading experience
  • Desirable

  • Experience in media development
  • Good understanding of cell function and metabolism
  • Experience in an industrial lab environment
  • Process development experience
  • GMP/GLP experience
  • Skills and Competencies

  • Disciplined, innovative, flexible and highly motivated
  • Strong team player but with the ability to work independently
  • Excellent communication skills (both written and verbal) are essential, as the team regularly interacts with research, preclinical and manufacturing groups internally and externally with CMOs and CROs.
  • Ability to follow SOPs
  • Ability to write SOPs, study protocols and reports
  • Problem solving abilities
  • Good time management
  • High attention to detail
  • Computer literate and ability to familiarise with different IT and database systems
  • Use of standard laboratory equipment (such as pipettes, centrifuges).
  • Advanced experimental design skills to address problems and scientific questions
  • Assay development experience
  • Multicolour flow cytometry experience
  • Desirable

  • Use of more specialist lab equipment (flow cytometers, cell counting equipment, cell washing and concentration equipment, bioreactors, ELISPOT and ELISA readers)
  • Technical interest
  • The role reports into the Cell Process Development Group Leader who has the overall responsibility
    for Cell Process Development. The job holder would work with the Cell PD Group
    Leader and Head of PD to define the strategy. The job holder would work
    collaborative with other functional experts both within the Cell PD team and
    with colleagues from Research and other departments.

    May lead projects in a matrix management setting.

    May have one or more direct reports.
    May help compile budgetary requirements.
    Occasional travel might be required.