Senior Scientist - DMPK
- Recruiter
- Charles River Laboratories
- Location
- Saffron Walden
- Salary
- Competitive
- Posted
- 25 Jun 2022
- Closes
- 02 Jul 2022
- Sectors
- Scientific & Pharmaceutical
- Contract Type
- Permanent
- Hours
- Full Time
For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about.
**Job Summary**
Charles River are looking for 2 x Senior Scientists, DMPK to grow our DMPK / ADME function, based at our Cambridge site in the UK. Individuals should have a desire to develop. At Charles Riverwe value the contributions individuals bring to the team so whether your focus is in-depth technical skills or expert DMPK drug discovery project support, the varied nature of our work offers opportunities to develop these.
*You will need:*
• Demonstrated practical experience of ADME assays, including automation, applied in a drug discovery setting
• Demonstrated experience of pharmacokinetic parameter determination and an understanding of the underlying principles
• An aptitude for understanding the impact DMPK data on drug discovery project progression
• A knowledge of the principles of PK/PD and PB/PK based modelling and simulation
• A passion for science; an interest in designing and performing mechanistic, bespoke studies to answer specific project related questions
• A desire to continually improve existing assays and processes to meet new standards or advances in scientific knowledge; essential to help us deliver the best to our clients
• Comprehensive trouble-shooting and problem solving skills both technical and scientific
• Attention to detail; getting it right the first time and quality control are at the heart of what we do
• Strong organization and time management skills alongside an inbuilt flexibility to adapt to change
• Excellent communication skills and be an effective team player; these will be essential to successful execution of projects whilst working in a matrix and multi-skilled environment.
**In return, you will have the opportunity to:**
• Be part of a multi-disciplinary team who are dedicated to partnering with our clients to discover quality candidate molecules
• Supportive of each other every step of the way
• Work in our modern laboratories based on a countryside science park close to Cambridge city Center.
• A total reward package that includes the opportunity for hybrid and flexible working, generous company pension contributions and the option for private medical and dental insurance. Full relocation assistance is available for the right candidate.
In addition, you can develop in an environment that empowers change to fulfil your ambitions and goals:
At Charles River we select our candidates not only on what they can do today but also on their potential for tomorrow. At the heart of Charles River's Career Development philosophy is our commitment to cultivating an environment where employees can thrive and unleash their hidden potential and talent to propel their career forward. This means giving our employees the opportunity to find roles or positions that fit their natural strengths and the ability to expand their range and grow their career at Charles River.
Join us as a Senior Scientist, DMPK today and with the support of your Manager and a bespoke Development Plan, you can grow into your future self. Here are a few ideas on what that destination could look like:
• Become a Technical Leader who uses their expert automation or assay method development knowledge to impact across multiple projects developing complex methods or implementing new approaches for the study of small molecules and new modalities
• Become a Research Leader who uses their modelling and simulations expertise to establish PK/PD or PB/PK relationships and guide project teams to the desired outcome
• Become a DMPK Discipline Lead or Project Leader for an integrated Drug Discovery Project; analysing, interpreting and integrating data to design the scientific strategy to deliver clinical candidates for our clients
• Become a Group Leader responsible for managing and developing a team of scientists and playing your part in the departmental management team
All roles involve mentoring and training others and promoting a collaborative culture across the Discovery DMPK function and beyond.
*About Discovery*
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350patents and 80preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.
*About Charles River*
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increasedto $2.62billion.
At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.
**Job Summary**
Charles River are looking for 2 x Senior Scientists, DMPK to grow our DMPK / ADME function, based at our Cambridge site in the UK. Individuals should have a desire to develop. At Charles Riverwe value the contributions individuals bring to the team so whether your focus is in-depth technical skills or expert DMPK drug discovery project support, the varied nature of our work offers opportunities to develop these.
*You will need:*
• Demonstrated practical experience of ADME assays, including automation, applied in a drug discovery setting
• Demonstrated experience of pharmacokinetic parameter determination and an understanding of the underlying principles
• An aptitude for understanding the impact DMPK data on drug discovery project progression
• A knowledge of the principles of PK/PD and PB/PK based modelling and simulation
• A passion for science; an interest in designing and performing mechanistic, bespoke studies to answer specific project related questions
• A desire to continually improve existing assays and processes to meet new standards or advances in scientific knowledge; essential to help us deliver the best to our clients
• Comprehensive trouble-shooting and problem solving skills both technical and scientific
• Attention to detail; getting it right the first time and quality control are at the heart of what we do
• Strong organization and time management skills alongside an inbuilt flexibility to adapt to change
• Excellent communication skills and be an effective team player; these will be essential to successful execution of projects whilst working in a matrix and multi-skilled environment.
**In return, you will have the opportunity to:**
• Be part of a multi-disciplinary team who are dedicated to partnering with our clients to discover quality candidate molecules
• Supportive of each other every step of the way
• Work in our modern laboratories based on a countryside science park close to Cambridge city Center.
• A total reward package that includes the opportunity for hybrid and flexible working, generous company pension contributions and the option for private medical and dental insurance. Full relocation assistance is available for the right candidate.
In addition, you can develop in an environment that empowers change to fulfil your ambitions and goals:
At Charles River we select our candidates not only on what they can do today but also on their potential for tomorrow. At the heart of Charles River's Career Development philosophy is our commitment to cultivating an environment where employees can thrive and unleash their hidden potential and talent to propel their career forward. This means giving our employees the opportunity to find roles or positions that fit their natural strengths and the ability to expand their range and grow their career at Charles River.
Join us as a Senior Scientist, DMPK today and with the support of your Manager and a bespoke Development Plan, you can grow into your future self. Here are a few ideas on what that destination could look like:
• Become a Technical Leader who uses their expert automation or assay method development knowledge to impact across multiple projects developing complex methods or implementing new approaches for the study of small molecules and new modalities
• Become a Research Leader who uses their modelling and simulations expertise to establish PK/PD or PB/PK relationships and guide project teams to the desired outcome
• Become a DMPK Discipline Lead or Project Leader for an integrated Drug Discovery Project; analysing, interpreting and integrating data to design the scientific strategy to deliver clinical candidates for our clients
• Become a Group Leader responsible for managing and developing a team of scientists and playing your part in the departmental management team
All roles involve mentoring and training others and promoting a collaborative culture across the Discovery DMPK function and beyond.
*About Discovery*
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350patents and 80preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.
*About Charles River*
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increasedto $2.62billion.
At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.